10093 - New Roles of Carboxypeptidase E in Endocrine and Neural Function and Cancer

Course Directors

Niamh X. Cawley, Ph.D., National Institutes of Health
Y. Peng Loh, Ph.D., National Institutes of Health
Saravana R. Murthy, Ph.D., National Institutes of Health
Karel Pacak, M.D., Ph.D., National Institutes of Health
Joshua J. Park, Ph.D., University of Toledo
William C. Wetsel, Ph.D., Duke University Medical Center

Description

This course reviews the phylogeny, structure and function of Carboxypeptidase E (CPE) in hormone and neuropeptide sorting and vesicle transport for secretion, alternative splicing of the CPE transcript and single nucleotide polymorphisms in humans. The course presents findings of important roles for CPE in the modulation of metabolic and glucose homeostasis, bone remodeling, obesity, fertility, neuroprotection, stress, sexual behavior, mood and emotional responses, and learning and memory. In addition, the course describes a splice variant form of CPE that has recently been found to be an inducer of tumor growth and metastasis, and a prognostic biomarker for metastasis in endocrine and non-endocrine tumors.

Credits

AMA PRA Category 1 Credits™

Opus Medicus designates this Internet enduring material for a maximum of 3.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Maintenance of Certification (MOC) Credits

In addition to AMA PRA Category 1 Credits™, Opus Medicus designates this course for Specialty Board MOC Program Credits:

3.0 ABIM MOC Points1

Accreditation Statement

Opus Medicus is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Tuition Fees

Course: Free
Credits: $78.00

Course Dates

Last Review Date: 07-Aug-2023
Expiration Date: 06-Aug-2026

Objectives

Participants completing this course will gain an understanding of:

1. The phylogeny, structure and function of Carboxypeptidase E (CPE) in hormone and neuropeptide sorting and vesicle transport.

2. Important roles for CPE in metabolic functions.

3. The connection between a variant of CPE and tumor growth and metastasis.

Topics

1. Introduction to functions of CPE

2. The CPE gene, biosynthesis, protein structure and distribution

3. CPE in prohormone sorting and vesicle transport

4. CPE action in the endocrine system - insights from mouse models

5. CPE in neural function and behavior

6. CPE and cancer in humans

7. Human CPE genetic mutations and disease

8. Conclusions

9. Future directions

American Board of Medical Specialties (ABMS) / Accreditation Council for Graduate Medical Education (ACGME) Competencies

☑  Patient Care (PC)
☑  Medical Knowledge (MK)

Financial Relationship Disclosure and Content Attestation

The course directors have no financial relationships with commercial entities producing healthcare related products and services relevant to the content of this course. Dr. Steven R. Tahan, Education Committee Chair, attests that commercial entities with which he has relationships do not produce healthcare related products or services relevant to the content of this course. No other person who has provided content for or who can influence the content of this course has disclosed financial relationships with commercial entities that produce health care-related products or services relevant to the course content.

There has been no commercial support for this course.

Supported Computer Hardware and Software Configurations2

Supported client computing platforms include:

A broadband Internet connection is required (e.g., cable, DSL, and 3G or 4G wireless). The course presentation is automatically scaled to the size of the display, from 800x480 pixels (minimum supported) to 1920x1200 pixels. On some smart phones, viewing courses may be tedious.

Supported browsers include:

Javascript, cookies, and popups must be enabled on your browser (which is the default configuration for most browsers).

1. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 3.0 MOC points for the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) Program, in addition to AMA PRA Category 1 Credits™. Participants will earn MOC points equivalent to the amount of AMA PRA Category 1 credits claimed for the activity. Immediately upon course completion, Opus Medicus will submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

2. The course may also be viewable on other client computing platforms that comply with Internet standards. If you experience technical problems that prevent you from viewing the course, we will promptly issue a full refund upon request.